Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?
作者： Aaron D. Benson , Melissa J. Slavin , Thanh-Thu Tran , Jeffrey R. Petrella , P. Murali Doraiswamy
DOI: 10.4088/PCC.V07N0204
关键词: Individual item 、 Internal medicine 、 Depression (differential diagnoses) 、 Receiver operating characteristic 、 Mini–Mental State Examination 、 Cognitive impairment 、 Normal aging 、 Psychiatry 、 Control subjects 、 Disease 、 Medicine
摘要: Background: The objective of this study was to compare the performance Mini-Mental State Examination (MMSE) total score as well item scores in separating 4 groups elderly (55–85 years age) subjects—normal controls, subjects with mild cognitive impairment (MCI), Alzheimer's disease, and depression. Method: MMSE 86 (25 normal 26 MCI, 10 25 depression) were analyzed. Statistically significant differences between both overall individual documented. Receiver operating characteristic curves constructed yield further data. Results: disease group significantly below those control, depression (p < .001). MCI lower than control = .005) but not different from depression. Furthermore, responses controls. delayed recall statistically versus other 3 did separate each other. Conclusion: effectively separates aging, it is relatively ineffective individuals Measures may need be implemented evaluate mental status more aging.
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