Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR).

摘要: Immunopharmacological studies of drugs used in cardiovascular diseases provide new data concerning their modulating effect on the levels proinflammatory cytokines, chemokines and adhesion molecules. Therefore, we have made an attempt to find out whether enalapril, quinapril losartan (drugs treatment arterial hypertension) are able modulate lipopolysaccharide (LPS)-induced cytokine serum concentrations (tumor necrosis factor alpha - TNF-alpha, interleukin-1 beta _ IL-1 beta, interleukin-6 IL-6) spontaneously hypertensive rats (SHR). The animals were divided into four groups as follows: SHR + M (control receiving 1% solution methylcellulose), E (rats enalapril 10 mg/kg), Q mg/kg) L(rats 20 mg/kg). methylcellulose hypotensive administered by a gavage for 21 days. Arterial blood pressure was measured conscious rats, using tail-cuff method. Twenty hours after last administration quinapril, or methylcellulose, received single dose LPS (ip; 0.1 After 2 h, anesthetized with ether samples collected heart puncture. Serum IL-6 enzyme-linked immunosorbent assay kits. Additionally, total cholesterol high density lipoprotein (HDL) evaluated. Enalapril, significantly decreased LPS-stimulated TNF-alpha level Three-week lowered concentration stimulation. Enalapril did not affect level. results accompanied statistically significant decrease systolic, diastolic mean pressure. Hypotensive also showed no lipid latest indicate additional properties drugs. However, further necessary elucidate precisely role cytokines hypertension.