Variation in antibiotic use across intensive care units (ICU): A population-based cohort study in Ontario, Canada.

摘要: OBJECTIVES Antibiotics are commonly used in intensive care units (ICUs), yet differences antibiotic use across ICUs unknown. Herein, we studied and examined factors that contributed to variation. METHODS We conducted a retrospective cohort study using data from Ontario's Critical Care Information System (CCIS), which included 201 adult 2,013,397 patient days January 2012 June 2016. Antibiotic was measured of therapy (DOT) per 1,000 days. ICU ability provide ventilator support (level 3) or not 2), type (medical-surgical other), academic status. Patient severity illness multiple-organ dysfunction score (MODS), ventilatory support, central venous catheter (CVC) use. analyzed the effect these on variation RESULTS Overall, 269,351 patients (56%) received antibiotics during their stay. The mean 624 (range 3-1460) DOT significantly higher medical-surgical compared other (697 vs 410 days; P < .0001) level 3 2 (751 513 .0001). Higher associated with intensity treatment. explained 47% ICUs. CONCLUSIONS varies widely ICUs, is partially characteristics. These highlight importance antimicrobial stewardship ensure appropriate patients.