A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers.

摘要: Abstract Objective To identify possible electroencephalographic (EEG) markers of donepezil’s effect on cortical activity in young, healthy adult volunteers at the group level. Methods Thirty subjects were administered a daily dose either 5 mg donepezil or placebo for 15 days double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations applied to EEG epochs. event-related potential (ERP), inter-trial coherence (ITC: phase consistency spectrum) and spectral perturbation (ERSP: power spectrum relative baseline) calculated target (oddball) stimuli. Results conditions differed terms changes delta/theta/alpha/beta ITC ERSP various regions (especially frontal electrodes) but not latency amplitude P300-ERP component. Conclusion Our results suggest that analyses can provide effects healthy, Significance Novel could be useful assess therapeutic drug candidates Alzheimer’s disease prior initiation Phase II/III clinical studies patients.