Age- and sex-related variability in physiological and immune responses to endotoxin challenge in Murrah buffaloes (Bubalus bubalis)

作者: Zahoor Ahmad Pampori , Sujata Pandita

DOI: 10.1080/09712119.2014.883318

关键词: Sex steroidHeart rateCytokineBubalusRespiration rateBiologyTumor necrosis factor alphaEndocrinologyInternal medicineImmune systemHormoneAnimal Science and ZoologyGeneral Veterinary

摘要: The host responses to disease agents differ between age and sex as is evidenced from epidemiological studies which have been ascribed the effects of steroid hormones. present study was carried out in 20 Murrah buffaloes either at pre- post-pubertal having discrete background explore variation, if any, physiological immune upon intravenous endotoxin challenge (E. coli 055:B5 @ 0.6µg/kg body weight). rectal temperature, heart rate respiration differed significantly base values only 1 h post reached peak 4 h. magnitude determined area under concentration × time curve (AUC) for these parameters low animals sex. Plasma tumour necrosis factor alpha (TNFα, a pro-inflammatory cytokine) registered returned level value by 8 challenge. Responses AUC TNFα were higher post-pubert...

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