Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation.

摘要: BACKGROUNDShort-term hibernating myocardium is characterized by a decrease in contractile function proportion to the reduced myocardial blood flow. Myocardial creatine phosphate content, initially decreased during first minutes of ischemia, returns near-control values, ischemia-induced net lactate production attenuated, and remains viable despite ongoing hypoperfusion dysfunction. Hibernating after 85 ischemia maintains an inotropic reserve responds short-term intracoronary dobutamine infusion with increased work; however, this response at expense metabolic recovery. We therefore hypothesized that development hibernation delicate process easily disturbed unfavorable alterations oxygen-supply demand balance.METHODS AND RESULTSTo study impact prolonged stimulation on hibernation, left anterior descending coronary artery w...