A versiconal hemiacetal acetate converting enzyme in aflatoxin biosynthesis.
作者： D. P. H. Hsieh , C. C. Wan , J. A. Billington
DOI: 10.1007/BF00707548
关键词: Chemistry 、 Hemiacetal 、 Biochemistry 、 High-performance liquid chromatography 、 Aflatoxin 、 Enzyme 、 Chloroform 、 Biosynthesis 、 Chromatography 、 Aspergillus parasiticus 、 Alcohol
摘要: Conversion of the aflatoxin biosynthetic intermediate versiconal hemiacetal acetate (VHA) in a cell free extract ofAspergillus parasiticus ATCC 15517 is investigated. The enzymatic reaction monitored by method using high performance liquid chromatography (HPLC). major product water soluble compound not chloroform-extractable at pH 7.5. becomes chloroform extractable upon acidification medium and separated quantitated reversed-phase HPLC. It tentatively identified as ‘versiconal alcohol,’ which converted to versicolorin C (VC) acid treatment.
springer.com
sci-hub.se 参考文章(12)
Richard J. Cole, Richard H. Cox, Handbook of toxic fungal metabolites Handbook of toxic fungal metabolites.. ,(1981)
H. W. Schroeder, R. J. Cole, R. D. Grigsby, H. Hein, Inhibition of Aflatoxin Production and Tentative Identification of an Aflatoxin Intermediate “Versiconal Acetate” from Treatment with Dichlorvos Applied Microbiology. ,vol. 27, pp. 394- 399 ,(1974) , 10.1128/AM.27.2.394-399.1974
D Bhatnagar, S P McCormick, L S Lee, R A Hill, Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus. Applied and Environmental Microbiology. ,vol. 53, pp. 1028- 1033 ,(1987) , 10.1128/AEM.53.5.1028-1033.1987
Raymond C. Yao, Dennis P. H. Hsieh, Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis Applied Microbiology. ,vol. 28, pp. 52- 57 ,(1974) , 10.1128/AM.28.1.52-57.1974
N C Wan, D P Hsieh, Enzymatic formation of the bisfuran structure in aflatoxin biosynthesis. Applied and Environmental Microbiology. ,vol. 39, pp. 109- 112 ,(1980) , 10.1128/AEM.39.1.109-112.1980
T E Cleveland, A R Lax, L S Lee, D Bhatnagar, Appearance of enzyme activities catalyzing conversion of sterigmatocystin to aflatoxin B1 in late-growth-phase Aspergillus parasiticus cultures. Applied and Environmental Microbiology. ,vol. 53, pp. 1711- 1713 ,(1987) , 10.1128/AEM.53.7.1711-1713.1987
Donald L. Fitzell, Rajendra Singh, Dennis P. H. Hsieh, Edwin L. Motell, Nuclear magnetic resonance identification of versiconal hemiacetal acetate as an intermediate in aflatoxin biosynthesis Journal of Agricultural and Food Chemistry. ,vol. 25, pp. 1193- 1197 ,(1977) , 10.1021/JF60213A024
J ADYE, R MATELES, INCORPORATION OF LABELLED COMPOUNDS INTO AFLATOXINS. Biochimica et Biophysica Acta. ,vol. 86, pp. 418- 420 ,(1964) , 10.1016/0304-4165(64)90077-7
J. J. Wong, D. P. Hsieh, Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential Proceedings of the National Academy of Sciences of the United States of America. ,vol. 73, pp. 2241- 2244 ,(1976) , 10.1073/PNAS.73.7.2241
D.G.I. Kingston, P.N. Chen, J.R. Vercellotti, High-performance liquid chromatography of sterigmatocystin and other metabolites of Aspergillus versicolor. Journal of Chromatography A. ,vol. 118, pp. 414- 417 ,(1976) , 10.1016/S0021-9673(00)82181-0