Validation and reduction of FACT/GOG‐Ntx subscale for platinum/paclitaxel‐induced neurologic symptoms: a gynecologic oncology group study

摘要: The FACT/GOG (Gynecologic Oncology Group) Neurotoxicity (Ntx) subscale for assessing platinum/paclitaxel-induced neurologic symptoms was evaluated. 11-item questionnaire administered to patients with advanced endometrial cancer treated doxorubicin/cisplatin (AP) or doxorubicin/cisplatin/paclitaxel (TAP) prior 1-7 cycles of treatment in GOG 177. evaluated 134 the TAP group internal reliability, construct validity, criteria sensitivity differences, and change over time. Cronbach coefficients consistency were 0.85, 0.80, 0.84, 0.82, respectively. area under receiver operating characteristic curve 0.81 Ntx score cycle 3. arm scores increased significantly from 3.67 at baseline 8.13 7; these higher than AP scores, which 3.54 4.72 7. four sensory items accounted 80% differences 63% longitudinal changes observed score. reliably validly assesses peripheral neuropathy. A reduced four-item version is an efficient alternative measuring this toxicity clinical trials without compromising its performance.