Investigation of p53, c-erbB-2, PCNA immunoreactivity, DNA content, AgNOR and apoptosis in bladder carcinoma as prognostic parameters
作者： Meral Koyuncuoğlu , Aydanur Kargı , Sultan Cingöz , Ziya Kırkalı
DOI: 10.1016/S0304-3835(97)00532-6
关键词: Carcinoma 、 Transitional cell carcinoma 、 Proliferating cell nuclear antigen 、 Tumor suppressor gene 、 Tumor progression 、 Prognostic variable 、 Gene expression 、 Apoptosis 、 Biology 、 Cancer research 、 Pathology
摘要: The association between known prognostic variables such as TNM stage, histological grade and mutant p53 tumor suppressor gene product, c-erbB-2 oncoprotein, DNA ploidy cell kinetic data, including mitoses, PCNA expression, AgNOR scores apoptosis, was investigated in 29 transitional carcinoma (TCC) cases. A positive correlation the histologic all studied parameters, except for a stage grade, ploidy, apoptosis expression were found. results of this study are accordance with some previous studies, which had been first time TCCs. Although we found statistically significant both predictive value an independent factor remains to be established larger series.
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