Vitamin K and hepatocellular carcinoma: The basic and clinic.

摘要: Vitamin K (VK), which was originally identified as a cofactor involved in the production of functional coagulation factors liver, has been shown to be various aspects physiological and pathological events, including bone metabolism, cardiovascular diseases tumor biology. The mechanisms roles VK are gradually becoming clear. Several novel enzymes cycle were have linked tumorigenesis. VKs suppress liver cancer cell growth through multiple signaling pathways via transcription protein kinases. A VK2 analog applied chemoprevention hepatocellular carcinoma (HCC) recurrence after curative therapy beneficial effects, both suppression HCC patient survival. Although large scale randomized control study failed demonstrate recurrence, meta-analysis suggested effect on long-term survival patients. However, effects administration alone not sufficient prevent or treat clinical settings. Thus its combination with other anti-cancer reagents development more potent derivatives focus ongoing research seeks achieve satisfactory therapeutic against HCC.