Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release
作者： Zeting Yuan , Yajing Ye , Feng Gao , Huihui Yuan , Minbo Lan
DOI: 10.1016/J.IJPHARM.2013.02.024
关键词: Chemistry 、 Drug delivery 、 Nanoparticle 、 Colloid 、 Chitosan 、 Nuclear chemistry 、 Organic chemistry 、 Polymer 、 Zeta potential 、 Controlled release 、 Cyclodextrin
摘要: Chitosan (CS) grafted with β-cyclodextrin (CD-g-CS) nanoparticles as a new carrier for poorly water-soluble drugs has been developed. The CD-g-CS polymer is readily synthesized from chitosan and mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin. Three different degrees of substitution (DS) (β-CD) on (9.6, 14.0 20.0%) are designed evaluated by controlling the mole ratio β-CD to chitosan. Then prepared an ionic gelation method, controlled size 202.0-589.0 nm. Stable colloidal dispersion formed zeta potential +23.0 +43.0 mV. In vitro stability test indicates that more stable in phosphate-buffered saline compared CS nanoparticles. Finally, drug, ketoprofen (KTP), used model drug evaluate efficiency delivery carrier. It found encapsulation KTP 20% DS CD high 1.36-fold than Moreover, notably released controlled-release manner pH-responsive CD. summary, these results suggest nanoparticles, general promising system, can be biodegradable nano-drug system release capability.
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