HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

作者: Andrea Sartore‐Bianchi , Alessio Amatu , Luca Porcu , Silvia Ghezzi , Sara Lonardi

DOI: 10.1634/THEONCOLOGIST.2018-0785

关键词: Clinical trialOdds ratioGrowth factor receptorBiomarker (medicine)OncologyColorectal cancerKRASInternal medicineMedicineBlockadeImmunohistochemistry

摘要: … ‐amplified metastatic CRC are less likely to respond to anti‐EGFR therapy. … ‐positive CRCs were defined by immunohistochemistry 3+ or 2+ in at least 50% of cells, confirmed by FISH. …

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