Effect of anticonvulsants on nocturnal sleep in epilepsy.

摘要: Our objective was to determine, in three separate studies, the effects of controlled-release carbamazepine (CBZ-CR), lamotrigine (LTG), and gabapentin (GBP) on nocturnal sleep epilepsy. Antiepileptic drugs (AEDs) control seizures also modify hypnic structure. Despite widespread clinical use, their are not well known. PSG performed all studies as follows: CBZ-CR: at baseline, after initial administration CBZ-CR 400 mg, 1 month treatment (400 mg BID) a sample seven temporal lobe epileptic (TLE) patients. Results were compared with those nine healthy volunteers; LTG: 3 months stable LTG (300 mg/day); GBP: GBP (1800 mg/day). Significant findings follows for each study. The acute increased number stage shifts, reduced REM sleep, fragmentation. In TLE group, these almost completely reversed chronic treatment. entries into decreased phase percentage slow-wave sleep. percentage, mean duration periods, awakenings, percentage. We conclude that disrupts but only during administration. improve stability while reducing seizures.