Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis

摘要: Ion channel currents, neural firing patterns, and brain BOLD signals display 1/f-type fluctuations or fractal properties in time. By design, fMRI methods attempt to minimize the contribution of variance from low-frequency physiological 1/f-noise. New are described visualize measure volunteers recalling affectively neutral emotional memories meditating (i.e., attending breathing) then retrospectively rating content. A wavelet scaling exponent ( α) was used characterize 0.015625 0.5 Hz cerebellar lobules VIII X vermis (posterior inferior vermis; PIV), a region coordinating balance, eye tracking, locomotion, vascular tone, possible site pathology attention deficit hyperactivity disorder (ADHD). Results: Changes α measures were correlated PIV voxels (r = 0.622, d.f. 14, P < 0.0005), but not other regions examined. In contrast, conventional means standard deviations unchanged. Methylphenidate, shown decrease slow oscillations rodent basal ganglia [Ruskin DN, Bergstrom DA, Shenker A, Freeman LE, Baek D, Walters JR. Drugs treatment attention-deficit/hyperactivity affect postsynaptic rate oscillation without preferential dopamine autoreceptor action. Biol Psychiatry 2001;49:340–50.], abolished task-dependent changes an adult with ADHD. Wavelet analysis long time series appears well suited physiology studies pharmacologically modulated cerebellar–thalamic–cortical function ADHD psychiatric disorders. © 2005 Elsevier B.V. All rights reserved.