Development and Validation of a N.O.V. (New, Original and Valid) Tool for Assessing the Quality of Individual Patient Data Meta-Analysis

摘要: Author(s): Arora, Rashi | Advisor(s): CHIAPPELLI, FRANCESCO Abstract: ABSTRACT OF THE THESISBackground.Evidence based Dentistry and Patient Centered Care are the two paradigms which influence process of clinical decision making in modern dental care. Although they complementary means to improve quality, may seem at odds with each other. In last decade, a need has emerged examine intersection these paradigms. Meta-analyses hallmark evidence dentistry as succeed showing statistically significant results by combining from individual studies. However, limited when studies heterogeneous. Meta-regression help investigate this heterogeneity, but its ability identify patient features related size treatment effect is answered using an data approach. Poor reporting meta-analysis diminishes value clinicians, policy makers, other users. Our goal develop validate tool assess quality meta-analysis.Methods. We on literature available field Individual meta-analysis. A modification PRISMA done without altering intent use. total, twelve meta-analyses oral maxillofacial medicine identified establish reliability. This carried out independent readers who standardized trained avoid misinterpretation Tool items. Pearson's r coefficient calculated test inter-rater; intra-rater reliability criterion validity.Results 9 item minimum 3 criteria per constructed. The lowest score possible question 1 highest 4. total maximum 36. new instrument high content validity virtue construction process. Testing for yields 0.957. construct Test content, Internal structure, Response process, Relations variables, Consequences testing. It also reliable 0.927 inter-rater 0.972 0.904 reliability.Discussion study led development novel specifically designed assessing scores 12 papers quantified degree paper satisfied certain that established determinant factors general, particular. implications clinicians researchers. recognize further testing increase validity. New areas methodology IPDMA call update Tool.