Plasma homocysteine in renal failure

摘要: Plasma homocysteine in three different groups of patients with chronic renal failure (one group without dialysis, one CAPD and hemodialysis) was increased compared to controls. Another slightly reduced dysfunction (normal serum creatinine but glomerular filtration rate) did not, however, show increase plasma homocysteine. The clearance as a percentage the also significantly Thus not affected same extent that failure. This may be attributed fact that, besides rate, depressed tubular uptake occur We were able neither varying function nor controls there any significant diurnal variation homocysteine, despite intake protein-rich meal. However, after methionine loading eight severe failure, slight noted. indicates disturbed metabolism high amounts which might mainly an impaired transulphuration pathway.