Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer's disease.
作者： Cuihua Zou , Jie Wang , Xiaohua Huang , Chongdong Jian , Donghua Zou
关键词: Ppi network 、 Computational biology 、 Biology 、 Gene Modules 、 Gene 、 Hub genes 、 Disease 、 Pathogenesis 、 Non-coding RNA 、 Transcription factor
摘要: Alzheimer's disease (AD) is a progressive neurodegenerative that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was identify functional modules, enrichment analysis showed they significantly involved "Alzheimer's disease", "apoptosis", related pathways. We predicted non-coding RNAs transcription factors may regulate modules. expression hub validated an independent data set. results this study provide several candidates for further research on mechanisms pathogenesis.
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