Cancer drug targeting

摘要: 'Now, if we were to succeed in discovering amongst these (chemoceptors) a receptor which was not represented the organs of host, would have possibility constructing an ideal medicament by selecting haptophore group that fits exclusively this particular parasite. A provided with such be entirely innocuous, because it is anchored organs; however strike parasites full force and, sense, correspond invasive substances, antibodies discovered Behring, manner magic bullets, seek out enemy. Let us hope will possible, chemotherapeutically, score bull's eyes way' (Ehrlich, 1913). Paul Ehrlich's famous vision has been turned into reality case many microbiological infections and as much cause for satisfaction our failure achieve cancer renewed effort. The idea neglected field but talk without fruition invitation boredom set in. Even Ehrlich probably realised analogy was, evocative, far-fetched 'magic bullet' molecule, sense seeking its target, require equipped equivalents both radar jet propulsion: tall order even today's ingenious molecular engineers. ballistic terminology lives on, however, concepts targets, carrier vehicles warheads. So may ask whether whole faintly potty. But before coming any damning conclusions should consider what conventional pharmacological agents. Perhaps approach development drugs coloured seemingly exquisite specificity digitalis. When alkaloid absorbed presumably delivered all body cells more or less uniformly only trival effect at therapeutic concentrations on most them profound those myocardium. It is, thus, cellular differentiation, phenotypic expression certain parts genome, confers associated If process malignant transformation Were confer properties unique myocardium conducting system, then effective anticancer might already identified. We expect lot from drugs. Like digitalis, they must leave vascular compartment crossing endothelial cell membranes extracellular space gain entry perform their action. This negligible generality lethal expressing characteristics cancer, whatever tissue differentiation cell. What remarkable do