Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup.

摘要: Genetic studies of clinically defined subgroups schizophrenia patients may reduce the phenotypic heterogeneity and thus facilitate identification genes that confer risk to this disorder. Several latent class analyses have provided psychotic disorders show considerable consistency over these studies. The presence or absence mood symptoms was found contribute most delineations subgroups. In study we used six previously published subtypes psychosis derived from analysis a large sample patients. 280 525 healthy controls investigated associations with myelin related genes. After bonferroni correction an association glycoprotein M6A gene (GPM6A) subgroup high levels depression (P-corrected = 0.006). Borderline microtubulin associated protein tau (MAPT) primarily non-affective group 0.052) also observed. GPM6A modulates influence stress on hippocampus in animals. Thus our findings could suggest GMP6A plays role stress-induced hippocampal alterations are psychiatric general particular. Overall, finding suggests investigating based profile particularly can genetic schizophrenia.