Autophagy as an immune defense mechanism
作者： Vojo Deretic
DOI: 10.1016/J.COI.2006.05.019
关键词: Biology 、 Autophagosome 、 Autophagy 、 Antigen processing 、 Intracellular parasite 、 Antigen presentation 、 Cell biology 、 Programmed cell death 、 Acquired immune system 、 Immune system
摘要: Autophagy is a homeostatic process whereby cytosol or intracellular organelles are sequestered by double membrane structure termed autophagosome for subsequent delivery to lysosomes and degradation. takes part in cell survival death has been implicated development, aging, neurodegeneration cancer. The newly discovered specialized role of autophagy immune cells expands autophagic functions defense against pathogens. Furthermore, involved acquired immunity, such as antigen processing MHC II presentation, modulated cytokines IFN-gamma. A further link emerged between pathogens via the immunity-related GTPase lrgm1 (LRG-47), which protective Mycobacterium tuberculosis. We propose term immunophagy these processes.
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