miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia
作者： Juhyun Song , Yumi Oh , Jong Eun Lee
关键词: Neuroscience 、 Microglia 、 Programmed cell death 、 Cell 、 Cell biology 、 Secretion 、 Biology 、 Autophagy 、 microRNA 、 Inflammation 、 Cytokine
摘要: Microglia regulate the secretion of various immunomediators in central nervous system diseases. Microglial autophagy is crucial process for cell's survival and cytokine productions. Recent studies have reported that several microRNAs are involved system. miR-Let7A such a microRNA plays role inflammation responses, magnified as key modulator particularly In present study, we investigated whether activating microglia. Overexpression LPS-stimulated BV2 microglial cells promoted induction related factors LC3II, Beclin1, ATG3. Our results suggest potential microglia during CNS inflammation.
en-journal.org参考文章(72)
Ralph A. Nixon, Jerzy Wegiel, Asok Kumar, Wai Haung Yu, Corrinne Peterhoff, Anne Cataldo, Ana Maria Cuervo, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 113- 122 ,(2005) , 10.1093/JNEN/64.2.113
A Rosello, G Warnes, UC Meier, None, Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die – that is the question Clinical and Experimental Immunology. ,vol. 168, pp. 52- 57 ,(2012) , 10.1111/J.1365-2249.2011.04544.X
Teng Jiang, Jin-Tai Yu, Xi-Chen Zhu, Hui-Fu Wang, Meng-Shan Tan, Lei Cao, Qiao-Quan Zhang, Li Gao, Jian-Quan Shi, Ying-Dong Zhang, Lan Tan, Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. British Journal of Pharmacology. ,vol. 171, pp. 3146- 3157 ,(2014) , 10.1111/BPH.12655
T. Zhang, H. Wang, Q. Li, J. Huang, X. Sun, Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model Neuroscience. ,vol. 263, pp. 130- 137 ,(2014) , 10.1016/J.NEUROSCIENCE.2014.01.012
Hasan Korkaya, Max S. Wicha, Inflammation and autophagy conspire to promote tumor growth. Cell Cycle. ,vol. 10, pp. 2623- 2624 ,(2011) , 10.4161/CC.10.16.16414
Jing Gan, Yi Qu, Jiao Li, Fengyan Zhao, Dezhi Mu, An evaluation of the links between microRNA, autophagy, and epilepsy Reviews in The Neurosciences. ,vol. 26, pp. 225- 237 ,(2015) , 10.1515/REVNEURO-2014-0062
Lei Song, Ming Su, Shuiyun Wang, Yubao Zou, Xiaojian Wang, Yilu Wang, Hongli Cui, Peng Zhao, Rutai Hui, Jizheng Wang, MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. Journal of Cellular and Molecular Medicine. ,vol. 18, pp. 2266- 2274 ,(2014) , 10.1111/JCMM.12380
D. R. Green, L. Galluzzi, G. Kroemer, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Science. ,vol. 333, pp. 1109- 1112 ,(2011) , 10.1126/SCIENCE.1201940
Michael P. Nelson, John J. Shacka, Autophagy Modulation in Disease Therapy: Where Do We Stand? Current Pathobiology Reports. ,vol. 1, pp. 239- 245 ,(2013) , 10.1007/S40139-013-0032-9
Kuninori Suzuki, Takayoshi Kirisako, Yoshiaki Kamada, Noboru Mizushima, Takeshi Noda, Yoshinori Ohsumi, The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation The EMBO Journal. ,vol. 20, pp. 5971- 5981 ,(2001) , 10.1093/EMBOJ/20.21.5971