Method of inhibiting and inducing human platelet aggregation
作者： Sheila Timmons , Marek Kloczewiak , Thomas J. Lukas , Jack J. Hawiger
DOI:
关键词: Pharmacology 、 Biochemistry 、 Thrombin 、 Blood proteins 、 Platelet 、 Human platelet 、 Chemistry 、 Fibrinogen 、 Platelet aggregation 、 Peptide
摘要: A method of inhibiting thrombin or ADP-induced human platelet aggregation by fibrinogen has been developed. The administration the small molecular weight peptide synthetic inhibitory molecule invention significantly inhibits ADP-modified platelets binding fibrinogen, a plasma protein necessary for aggregation. is useful formation hemostatic plugs and initiation thrombotic lesions. blockage caused damage lesions are major factors in heart disease stroke. also includes inducing aggregates aggregating which represents functional substitute fibrinogen.
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