[Ru(TAP)2(dppz)]2+: a DNA intercalating complex, which luminesces strongly in water and undergoes photo-induced proton-coupled electron transfer with guanosine-5′-monophosphate
作者： Isabelle Ortmans , Benjamin Elias , John M. Kelly , Cécile Moucheron , Andrée Kirsch-DeMesmaeker
DOI: 10.1039/B313213G
关键词: Guanosine 、 Quenching (fluorescence) 、 Electron transfer 、 Phenazine 、 Photochemistry 、 Excited state 、 Ligand 、 Chemistry 、 Flash photolysis 、 Proton-coupled electron transfer
摘要: The lowest excited state of [Ru(TAP)2(dppz)]2+ (TAP = 1,4,5,8-tetraazaphenanthrene, dppz dipyrido[3,2-a:2′,3′-c]phenazine) 1 is strongly luminescent, even in water, and very oxidizing. Therefore it able to oxidise not only guanosine-5′-monophosphate (GMP), as demonstrated by laser flash photolysis, but also guanine-containing polynucleotides such calf thymus DNA [poly(dG–dC)]2. luminescence quenching was found be faster H2O than D2O, the back reaction, indicating that both processes probably proceed proton-coupled electron transfer. These properties, are controlled triplet MLCT which charge has been transferred from Ru a TAP ligand, contrast with those well known [Ru(phen)2(dppz)]2+2.
rsc.org
ulb.ac.be
sci-hub.se 参考文章(52)
J.-B. Lepecq, C. Paoletti, A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization. Journal of Molecular Biology. ,vol. 27, pp. 87- 106 ,(1967) , 10.1016/0022-2836(67)90353-1
Claudia Turro, Stefan H. Bossmann, Yonchu Jenkins, Jacqueline K. Barton, Nicholas J. Turro, Proton Transfer Quenching of the MLCT Excited State of Ru(phen)2dppz2+ in Homogeneous Solution and Bound to DNA Journal of the American Chemical Society. ,vol. 117, pp. 9026- 9032 ,(1995) , 10.1021/JA00140A020
A. Juris, V. Balzani, F. Barigelletti, S. Campagna, P. Belser, A. von Zelewsky, Ru(II) polypyridine complexes: photophysics, photochemistry, eletrochemistry, and chemiluminescence Coordination Chemistry Reviews. ,vol. 84, pp. 85- 277 ,(1988) , 10.1016/0010-8545(88)80032-8
Matthew K. Brennaman, James H. Alstrum-Acevedo, Cavan N. Fleming, Paul Jang, Thomas J. Meyer, John M. Papanikolas, Turning the [Ru(bpy)2dppz]2+ light-switch on and off with temperature. Journal of the American Chemical Society. ,vol. 124, pp. 15094- 15098 ,(2002) , 10.1021/JA0279139
My Hang V. Huynh, Thomas J. Meyer, Peter S. White, Proton-Coupled Electron Transfer from Nitrogen. A N−H/N−D Kinetic Isotope Effect of 41.4 Journal of the American Chemical Society. ,vol. 121, pp. 4530- 4531 ,(1999) , 10.1021/JA984325F
George Scatchard, The Attractions of Proteins for Small Molecules and Ions Annals of the New York Academy of Sciences. ,vol. 51, pp. 660- 672 ,(1949) , 10.1111/J.1749-6632.1949.TB27297.X
Cynthia M. Dupureur, Jacqueline K. Barton, Use of Selective Deuteration and 1H NMR in Demonstrating Major Groove Binding of .DELTA.-[Ru(phen)2dppz]2+ to d(GTCGAC)2 Journal of the American Chemical Society. ,vol. 116, pp. 10286- 10287 ,(1994) , 10.1021/JA00101A053
Fre´de´ric Pierard, Andre´ Del Guerzo, Andre´e Kirsch-De Mesmaeker, Martine Demeunynck, Jean Lhomme, Quantitative analysis of the effect of derivatisation of [Ru(BPY)2phen]2+ with a quinoline moiety on the interaction with DNA Physical Chemistry Chemical Physics. ,vol. 3, pp. 2911- 2920 ,(2001) , 10.1039/B101298N
James D. McGhee, Peter H. von Hippel, Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. Journal of Molecular Biology. ,vol. 86, pp. 469- 489 ,(1974) , 10.1016/0022-2836(74)90031-X
Stephanie C. Weatherly, Ivana V. Yang, Paul A. Armistead, H. Holden Thorp, Proton-Coupled Electron Transfer in Guanine Oxidation: Effects of Isotope, Solvent, and Chemical Modification Journal of Physical Chemistry B. ,vol. 107, pp. 372- 378 ,(2003) , 10.1021/JP022085R