Biodegradable poly(glycerin citrate) and its application to controlled release of theophylline
作者： Shixin Liu , Man Jiang , Sai Ye , Xiaohong Xu , Ping Lu
DOI: 10.1002/APP.34886
关键词: Condensation polymer 、 Permeation 、 Dynamic mechanical analysis 、 Polyester 、 Drug control 、 Citric acid 、 Polymer chemistry 、 Materials science 、 Glass transition 、 Chemical engineering 、 Controlled release
摘要: This study reports properties of a class biodegradable polyesters based on citric acid and glycerin, both which are safe ingredients in food, their usefulness for drug control release applications. Transparent thin films poly(glycerin citrate) (PGC) prepared by condensation polymerization were characterized dynamic mechanical analysis, tensile testing, FTIR spectroscopy. Depending the acid-to-glycerin molar ratios, crosslinked could have glass transition temperatures varying from 30 to 81°C as shown analysis. The ductile PGC more prone hydrolytic degradation than poly(lactic acid). controlled evaluated permeation an exemplary theophylline. diffusion theophylline film follows Super Case II mechanism, but modified with PEG4000, approximately mechanism (near zero-order mechanism). © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
sci-hub.se 参考文章(23)
A.A. Woodcock, M.A. Johnson, D.M. Geddes, THEOPHYLLINE PRESCRIBING, SERUM CONCENTRATIONS, AND TOXICITY The Lancet. ,vol. 322, pp. 610- 613 ,(1983) , 10.1016/S0140-6736(83)90691-8
Nicholas A. Peppas, Shelia L. Wright, Drug diffusion and binding in ionizable interpenetrating networks from poly(vinyl alcohol) and poly(acrylic acid) European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 46, pp. 15- 29 ,(1998) , 10.1016/S0939-6411(97)00113-6
Leslie Hendeles, Miles Weinberger, George Johnson, Monitoring serum theophylline levels. Clinical Pharmacokinectics. ,vol. 3, pp. 294- 312 ,(1978) , 10.2165/00003088-197803040-00003
Denise D. Deppe, Ali Dhinojwala, John M. Torkelson, Small molecule probe diffusion in thin polymer films near the glass transition: A novel approach using fluorescence nonradiative energy transfer Macromolecules. ,vol. 29, pp. 3898- 3908 ,(1996) , 10.1021/MA960024J
Yadong Wang, Guillermo A. Ameer, Barbara J. Sheppard, Robert Langer, A tough biodegradable elastomer Nature Biotechnology. ,vol. 20, pp. 602- 606 ,(2002) , 10.1038/NBT0602-602
Naoto Tsutsumi, Masaya Oya, Wataru Sakai, Biodegradable Network Polyesters from Gluconolactone and Citric Acid Macromolecules. ,vol. 37, pp. 5971- 5976 ,(2004) , 10.1021/MA049607G
Ayse Z Aroguz, Kemal Baysal, Betul Tasdelen, Bahattin M Baysal, None, Preparation, characterization, and swelling and drug release properties of a crosslinked chitosan‐polycaprolactone gel Journal of Applied Polymer Science. ,vol. 119, pp. 2885- 2894 ,(2011) , 10.1002/APP.33074
Rahul Bhardwaj, Amar K. Mohanty, Modification of brittle polylactide by novel hyperbranched polymer-based nanostructures. Biomacromolecules. ,vol. 8, pp. 2476- 2484 ,(2007) , 10.1021/BM070367X
Lei Jin, Ping Lu, Huanhuan You, Qiang Chen, Jian Dong, Vitamin B12 diffusion and binding in crosslinked poly(acrylic acid)s and poly(acrylic acid-co-N-vinyl pyrrolidinone)s. International Journal of Pharmaceutics. ,vol. 371, pp. 82- 88 ,(2009) , 10.1016/J.IJPHARM.2008.12.022
Ivan Djordjevic, Namita Roy Choudhury, Naba K. Dutta, Sunil Kumar, Synthesis and characterization of novel citric acid-based polyester elastomers Polymer. ,vol. 50, pp. 1682- 1691 ,(2009) , 10.1016/J.POLYMER.2009.01.045