Visible light-induced 3-sulfenylation of N-methylindoles with arylsulfonyl chlorides

作者: Min Chen , Zhi-Tang Huang , Qi-Yu Zheng

DOI: 10.1039/C2CC36866H

关键词: Visible spectrumStereochemistryMedicinal chemistryChemistry

摘要: Visible light-induced 3-sulfenylation of N -methylindoles with arylsulfonyl chlorides - Chemical Communications (RSC Publishing) DOI:10.1039/C2CC36866H … o-, m- or p-Toluene sulfonyl chlorides and benzene sulfonyl chloride could be utilized to give the corresponding products 3 in moderate yields (Table 1, 3a–d). Steric hindrance of o-methyl made the reaction sluggish, with longer reaction time and lower yield (Table 1, 3b). Sulfenylating reagents 2 bearing both electron-donating (Table 1, 3h) as well as electron-withdrawing …

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