Diagnostic Criteria for Autoimmune Hepatitis : Historical Review and Present Problems

摘要: Autoimmune hepatitis (AIH) is a chronic of unexplained etiology. Because no specific clinical marker has been identified, ruling out other liver diseases known etiology important when diagnosing AIH. The International Hepatitis Group (IAIHG) prepared diagnostic criteria aimed at standardizing diagnosis. IAIHG scoring system used extensively for However, because this covers variety elements, using it the bedside can be difficult. Recently, proposed simplified composed only 4 elements which reportedly excellent capabilities. Problems have also identified in assays serum autoantibodies. Although recommends indirect immunofluorescent method with frozen sections rodent liver, kidney, and stomach to check autoantibodies involved AIH, now few institutions, enzymelinked immunosorbent assay established cell lines are more widely used. In any event, autoantibody detection must standardized quantified. Liver biopsy diagnosis ; however, histological findings not always specific. review we describe history AIH related problems. (Jikeikai Med J 2011 58 : 89-93)