Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.
作者： Maria C. Velásquez-Martínez , Rafael Vázquez-Torres , Legier V. Rojas , Priscila Sanabria , Carlos A. Jiménez-Rivera
DOI: 10.1016/J.NEUROPHARM.2014.09.002
关键词: Phenylephrine 、 Neuroscience 、 Ventral tegmental area 、 Inhibitory postsynaptic potential 、 GABAergic 、 Internal medicine 、 gamma-Aminobutyric acid 、 Patch clamp 、 Endocrinology 、 Agonist 、 Dopamine 、 Chemistry
摘要: Abstract The ventral tegmental area (VTA) plays an important role in reward and motivational processes involved drug addiction. Previous studies have shown that alpha1-adrenoreceptors (α1-AR) are primarily found pre-synaptically at this area. We hypothesized GABA released onto VTA-dopamine (DA) cells is modulated by pre-synaptic α1-AR. Recordings were obtained from putative VTA-DA of male Sprague–Dawley rats (28–50 days postnatal) using whole-cell voltage clamp technique. Phenylephrine (10 μM; α1-AR agonist) decreased the amplitude A receptor-mediated inhibitory postsynaptic currents (IPSCs) evoked electrical stimulation afferent fibers ( n = 7; p = 13; = 9; > 0.05). low Ca 2+ (1 mM) medium IPSC = 6; This article part Special Issue entitled ‘GABAergic Signaling Health Disease’.
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