Individual Variability in the Frequency of Sister Chromatid Exchange in Human Lymphocytes
作者： Bo Lambert , Robert Olin
DOI: 10.1007/978-1-4613-2765-3_11
关键词: In vitro 、 Carcinogen 、 DNA replication 、 Molecular biology 、 Metaphase 、 Single gene mutation 、 Sister chromatid exchange 、 Chemical agents 、 Chromosome aberration 、 Chemistry
摘要: Sister chromatid exchange (SCE) can be demonstrated in metaphase cells by autoradiographic techniques [1] or more recently developed staining [2]. Although the mechanism(s) and nature of alterations leading to SCE are largely unknown, there a number observations suggesting relationship between mutagenic and/or carcinogenic damage an increased rate SCEs [3]. Firstly is linear correlation induction single gene mutation for many chemical agents, both these events show similar spontaneous occurrence over entire genome [4]. Secondly, great mutagens carcinogens have been shown induce SCEs, some cases at very low concentrations, various mammalian cellsin vitro as well asin vivo [5, 6]. Finally, S-phase dependent, appears closely related DNA replication
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