Olfactory Map Formation in the Mouse

作者: Hitoshi Sakano

DOI: 10.1007/978-4-431-54376-3_3

关键词: G protein-coupled receptorOdorProjection (mathematics)Olfactory systemNeuroscienceOlfactory epitheliumBiologyOlfactory bulbTopographic map (neuroanatomy)Sensory neuron

摘要: In the mouse olfactory system, each sensory neuron (OSN) expresses only one functional odorant receptor (OR) species. Furthermore, OSN axons bearing same OR converge to a specific projection site in bulb (OB), forming glomerular structure. Based on these two basic principles, odor information detected epithelium is converted topographic map of activated glomeruli OB. During embryonic development, formed by combination genetically programmed processes. One OR-dependent along anterior-posterior axis, and other OR-independent dorsal-ventral axis. The further refined an activity-dependent manner during neonatal period. Here, we discuss recent progress neural formation system.

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