A supersized list of obesity genes

Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul IW de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen, Kristin Ardlie, Kristina Bengtsson Boström, Richard N Bergman, Lori L Bonnycastle, Knut Borch-Johnsen, Noël P Burtt, Hong Chen, Peter S Chines, Mark J Daly, Parimal Deodhar, Chia-Jen Ding, Alex SF Doney, William L Duren, Katherine S Elliott, Michael R Erdos, Timothy M Frayling, Rachel M Freathy, Lauren Gianniny, Harald Grallert, Niels Grarup, Christopher J Groves, Candace Guiducci, Torben Hansen, Christian Herder, Graham A Hitman, Thomas E Hughes, Bo Isomaa, Anne U Jackson, Torben Jørgensen, Augustine Kong, Kari Kubalanza, Finny G Kuruvilla, Johanna Kuusisto, Claudia Langenberg, Hana Lango, Torsten Lauritzen, Yun Li, Cecilia M Lindgren, Valeriya Lyssenko, Amanda F Marvelle, Christa Meisinger, Kristian Midthjell, Karen L Mohlke, Mario A Morken, Andrew D Morris, Narisu Narisu, Peter Nilsson, Katharine R Owen, Colin NA Palmer, Felicity Payne, John RB Perry, Elin Pettersen, Carl Platou, Inga Prokopenko, Lu Qi, Li Qin, Nigel W Rayner, Matthew Rees, Jeffrey J Roix, Anelli Sandbaek, Beverley Shields, Marketa Sjögren, Valgerdur Steinthorsdottir, Heather M Stringham, Amy J Swift, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Nicholas J Timpson, Tiinamaija Tuomi, Jaakko Tuomilehto, Mark Walker, Richard M Watanabe, Michael N Weedon, Cristen J Willer, Wellcome Trust Case Control Consortium, Thomas Illig, Kristian Hveem, Frank B Hu, Markku Laakso, Kari Stefansson, Oluf Pedersen, Nicholas J Wareham, Inês Barroso, Andrew T Hattersley, Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler, None, Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nature Genetics. ,vol. 40, pp. 638- 645 ,(2008) , 10.1038/NG.120

Michael Benzinou, John W M Creemers, Helene Choquet, Stephane Lobbens, Christian Dina, Emmanuelle Durand, Audrey Guerardel, Philippe Boutin, Beatrice Jouret, Barbara Heude, Beverley Balkau, Jean Tichet, Michel Marre, Natascha Potoczna, Fritz Horber, Catherine Le Stunff, Sebastien Czernichow, Annelli Sandbaek, Torsten Lauritzen, Knut Borch-Johnsen, Gitte Andersen, Wieland Kiess, Antje Körner, Peter Kovacs, Peter Jacobson, Lena M S Carlsson, Andrew J Walley, Torben Jørgensen, Torben Hansen, Oluf Pedersen, David Meyre, Philippe Froguel, Common nonsynonymous variants in PCSK1 confer risk of obesity Nature Genetics. ,vol. 40, pp. 943- 945 ,(2008) , 10.1038/NG.177

Sue Shackleton, David J Lloyd, Stephen NJ Jackson, Richard Evans, Martinus F Niermeijer, Baldev M Singh, Hartmut Schmidt, Georg Brabant, Sudesh Kumar, Paul N Durrington, Simon Gregory, Stephen O'Rahilly, Richard C Trembath, None, LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nature Genetics. ,vol. 24, pp. 153- 156 ,(2000) , 10.1038/72807

David Meyre, Jérôme Delplanque, Jean-Claude Chèvre, Cécile Lecoeur, Stéphane Lobbens, Sophie Gallina, Emmanuelle Durand, Vincent Vatin, Franck Degraeve, Christine Proença, Stefan Gaget, Antje Körner, Peter Kovacs, Wieland Kiess, Jean Tichet, Michel Marre, Anna-Liisa Hartikainen, Fritz Horber, Natascha Potoczna, Serge Hercberg, Claire Levy-Marchal, François Pattou, Barbara Heude, Maithé Tauber, Mark I McCarthy, Alexandra I F Blakemore, Alexandre Montpetit, Constantin Polychronakos, Jacques Weill, Lachlan J M Coin, Julian Asher, Paul Elliott, Marjo-Riitta Järvelin, Sophie Visvikis-Siest, Beverley Balkau, Rob Sladek, David Balding, Andrew Walley, Christian Dina, Philippe Froguel, Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations Nature Genetics. ,vol. 41, pp. 157- 159 ,(2009) , 10.1038/NG.301

Timothy M Frayling, Nicholas J Timpson, Michael N Weedon, Eleftheria Zeggini, Rachel M Freathy, Cecilia M Lindgren, John RB Perry, Katherine S Elliott, Hana Lango, Nigel W Rayner, Beverley Shields, Lorna W Harries, Jeffrey C Barrett, Sian Ellard, Christopher J Groves, Bridget Knight, Ann-Marie Patch, Andrew R Ness, Shah Ebrahim, Debbie A Lawlor, Susan M Ring, Yoav Ben-Shlomo, Marjo-Riitta Jarvelin, Ulla Sovio, Amanda J Bennett, David Melzer, Luigi Ferrucci, Ruth JF Loos, Inês Barroso, Nicholas J Wareham, Fredrik Karpe, Katharine R Owen, Lon R Cardon, Mark Walker, Graham A Hitman, Colin NA Palmer, Alex SF Doney, Andrew D Morris, George Davey Smith, Andrew T Hattersley, Mark I McCarthy, None, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science. ,vol. 316, pp. 889- 894 ,(2007) , 10.1126/SCIENCE.1141634

Ruth JF Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M Freathy, Antony P Attwood, Jacques S Beckmann, Sonja I Berndt, Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial Jacobs Kevin B 53 Chanock Stephen J 11 54 Hayes Richard B 11, Sven Bergmann, Amanda J Bennett, Sheila A Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex SF Doney, Katherine S Elliott, Paul Elliott, David M Evans, I Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J Groves, Rhian Gwilliam, David Hadley, Alistair S Hall, Andrew T Hattersley, Johannes Hebebrand, Iris M Heid, KORA Lamina Claudia 29 Gieger Christian 29 30 Illig Thomas 29 Meitinger Thomas 55 56 Wichmann H-Erich 29 30, Blanca Herrera, Anke Hinney, Sarah E Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer DM Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N Luben, Massimo Mangino, Jonathan Marchini, Wendy L McArdle, Ralph McGinnis, David Meyre, Patricia B Munroe, Andrew D Morris, Andrew R Ness, Matthew J Neville, Alexandra C Nica, Ken K Ong, Stephen O'Rahilly, Katharine R Owen, Colin NA Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study Kraft Peter 57 Hankinson Susan E 58 Hunter David J 40 44 57 58 Hu Frank B 40 58, Joshua C Randall, Nigel W Rayner, Susan M Ring, Manjinder S Sandhu, André Scherag, Matthew A Sims, Kijoung Song, Nicole Soranzo, Elizabeth K Speliotes, Diabetes Genetics Initiative Lyon Helen N 44 48 50 Voight Benjamin F 44 59 60 61 Ridderstrale Martin 62 Groop Leif 62 63, Holly E Syddall, Sarah A Teichmann, Nicholas J Timpson, Jonathan H Tobias, Manuela Uda, SardiNIA Study Scheet Paul 64 Sanna Serena 46 Abecasis Goncalo R 64 Albai Giuseppe 46 Nagaraja Ramaiah 65 Schlessinger David 65, Carla I Ganz Vogel, Chris Wallace, Dawn M Waterworth, Michael N Weedon, Wellcome Trust Case Control Consortium, Cristen J Willer, FUSION Jackson Anne U 47 Tuomilehto Jaakko 66 66 68 Collins Francis S 69 Boehnke Michael 47 Mohlke Karen L 70, Vicki L Wraight, Xin Yuan, Eleftheria Zeggini, Joel N Hirschhorn, David P Strachan, Willem H Ouwehand, Mark J Caulfield, Nilesh J Samani, Timothy M Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham, Inês Barroso, None, Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics. ,vol. 40, pp. 768- 775 ,(2008) , 10.1038/NG.140

T. Pischon, H. Boeing, K. Hoffmann, M. Bergmann, M.B. Schulze, K. Overvad, Y.T. van der Schouw, E. Spencer, K.G.M. Moons, A. Tjønneland, J. Halkjaer, M.K. Jensen, J. Stegger, F. Clavel-Chapelon, M.-C. Boutron-Ruault, V. Chajes, J. Linseisen, R. Kaaks, A. Trichopoulou, D. Trichopoulos, C. Bamia, S. Sieri, D. Palli, R. Tumino, P. Vineis, S. Panico, P.H.M. Peeters, A.M. May, H.B. Bueno-de-Mesquita, F.J.B. van Duijnhoven, G. Hallmans, L. Weinehall, J. Manjer, B. Hedblad, E. Lund, A. Agudo, L. Arriola, A. Barricarte, C. Navarro, C. Martinez, J.R. Quirós, T. Key, S. Bingham, K.T. Khaw, P. Boffetta, M. Jenab, P. Ferrari, E. Riboli, General and abdominal adiposity and risk of death in Europe. The New England Journal of Medicine. ,vol. 359, pp. 2105- 2120 ,(2008) , 10.1056/NEJMOA0801891

Cristen J Willer, Elizabeth K Speliotes, Ruth JF Loos, Shengxu Li, Cecilia M Lindgren, Iris M Heid, Sonja I Berndt, Amanda L Elliott, Anne U Jackson, Claudia Lamina, Guillaume Lettre, Noha Lim, Helen N Lyon, Steven A McCarroll, Konstantinos Papadakis, Lu Qi, Joshua C Randall, Rosa Maria Roccasecca, Serena Sanna, Paul Scheet, Michael N Weedon, Eleanor Wheeler, Jing Hua Zhao, Leonie C Jacobs, Inga Prokopenko, Nicole Soranzo, Toshiko Tanaka, Nicholas J Timpson, Peter Almgren, Amanda Bennett, Richard N Bergman, Sheila A Bingham, Lori L Bonnycastle, Morris Brown, Noël P Burtt, Peter Chines, Lachlan Coin, Francis S Collins, John M Connell, Cyrus Cooper, George Davey Smith, Elaine M Dennison, Parimal Deodhar, Paul Elliott, Michael R Erdos, Karol Estrada, David M Evans, Lauren Gianniny, Christian Gieger, Christopher J Gillson, Candace Guiducci, Rachel Hackett, David Hadley, Alistair S Hall, Aki S Havulinna, Johannes Hebebrand, Albert Hofman, Bo Isomaa, Kevin B Jacobs, Toby Johnson, Pekka Jousilahti, Zorica Jovanovic, Kay-Tee Khaw, Peter Kraft, Mikko Kuokkanen, Johanna Kuusisto, Jaana Laitinen, Edward G Lakatta, Jian'an Luan, Robert N Luben, Massimo Mangino, Wendy L McArdle, Thomas Meitinger, Antonella Mulas, Patricia B Munroe, Narisu Narisu, Andrew R Ness, Kate Northstone, Stephen O'Rahilly, Carolin Purmann, Matthew G Rees, Martin Ridderstråle, Susan M Ring, Fernando Rivadeneira, Aimo Ruokonen, Manjinder S Sandhu, Jouko Saramies, Laura J Scott, Angelo Scuteri, Kaisa Silander, Matthew A Sims, Kijoung Song, Jonathan Stephens, Suzanne Stevens, Heather M Stringham, YC Loraine Tung, Timo T Valle, Cornelia M Van Duijn, Karani S Vimaleswaran, Peter Vollenweider, Gerard Waeber, Chris Wallace, Richard M Watanabe, Dawn M Waterworth, Nicholas Watkins, Jacqueline CM Witteman, Eleftheria Zeggini, Guangju Zhai, M Carola Zillikens, David Altshuler, Mark J Caulfield, Stephen J Chanock, I Sadaf Farooqi, Luigi Ferrucci, Jack M Guralnik, Andrew T Hattersley, Frank B Hu, Marjo-Riitta Jarvelin, Markku Laakso, Vincent Mooser, Ken K Ong, Willem H Ouwehand, Veikko Salomaa, Nilesh J Samani, Timothy D Spector, Tiinamaija Tuomi, Jaakko Tuomilehto, Manuela Uda, André G Uitterlinden, Nicholas J Wareham, Panagiotis Deloukas, Timothy M Frayling, Leif C Groop, Richard B Hayes, David J Hunter, Karen L Mohlke, Leena Peltonen, David Schlessinger, David P Strachan, H-Erich Wichmann, Mark I McCarthy, Michael Boehnke, Inês Barroso, Gonçalo R Abecasis, Joel N Hirschhorn, Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Nature Genetics. ,vol. 41, pp. 25- 34 ,(2009) , 10.1038/NG.287

Gudmar Thorleifsson, G Bragi Walters, Daniel F Gudbjartsson, Valgerdur Steinthorsdottir, Patrick Sulem, Anna Helgadottir, Unnur Styrkarsdottir, Solveig Gretarsdottir, Steinunn Thorlacius, Ingileif Jonsdottir, Thorbjorg Jonsdottir, Elinborg J Olafsdottir, Gudridur H Olafsdottir, Thorvaldur Jonsson, Frosti Jonsson, Knut Borch-Johnsen, Torben Hansen, Gitte Andersen, Torben Jorgensen, Torsten Lauritzen, Katja K Aben, André LM Verbeek, Nel Roeleveld, Ellen Kampman, Lisa R Yanek, Lewis C Becker, Laufey Tryggvadottir, Thorunn Rafnar, Diane M Becker, Jeffrey Gulcher, Lambertus A Kiemeney, Oluf Pedersen, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson, Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity Nature Genetics. ,vol. 41, pp. 18- 24 ,(2009) , 10.1038/NG.274

D. B. Savage, G. D. Tan, C. L. Acerini, S. A. Jebb, M. Agostini, M. Gurnell, R. L. Williams, A. M. Umpleby, E. L. Thomas, J. D. Bell, A. K. Dixon, F. Dunne, R. Boiani, S. Cinti, A. Vidal-Puig, F. Karpe, V. K. K. Chatterjee, S. O'Rahilly, Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ Diabetes. ,vol. 52, pp. 910- 917 ,(2003) , 10.2337/DIABETES.52.4.910