High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients
作者： Hirokazu Honda , Tetsuo Michihata , Kanji Shishido , Keiko Takahashi , Go Takahashi
DOI: 10.1371/JOURNAL.PONE.0176984
关键词: Medicine 、 Fibroblast growth factor 23 、 Endocrinology 、 Hemoglobin 、 Anemia 、 Transferrin saturation 、 Prospective cohort study 、 Hemodialysis 、 Internal medicine 、 Ferritin 、 Dialysis
摘要: A recent study demonstrated the association between inflammation, iron metabolism and fibroblast growth factor (FGF) 23. The present clinical aimed to assess associations anemia, FGF23 in hemodialysis (HD) patients. This prospective observational examined a cohort of prevalent HD patients (n = 282). Blood samples were obtained before dialysis sessions measure baseline levels hemoglobin (Hb), transferrin saturation (TSAT), ferritin, albumin-adjusted calcium (Ca), phosphate (P), intact (i)-PTH, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin (i)-FGF23, high sensitive (hs)-CRP, interleukin-6. After measurement, followed-up for 6 months. Biochemical measurements subsequently performed at 1 2 (TSAT ferritin) or 3 (Ca, P hs-CRP) month intervals. Doses ESAs intravenous supplementation during period recorded. i-FGF23 was positively correlated with Ca, P, i-PTH inversely TSAT ferritin. However, Hb hs-CRP doses did not differ among tertiles, ferritin higher tertile being consistently lower than middle tertiles. Multivariate repeated measures analysis indicated that independently associated but TSAT. significantly increased multivariate models. In conclusion, may be prolongation low resulting usages
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