Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity
作者： Céline Demougeot , Paul Walker , Alain Beley , Christine Marie , Olivier Rouaud
DOI: 10.1016/S0022-510X(02)00109-0
关键词: Hyperintensity 、 Pathology 、 T2 weighted 、 Stroke 、 Ischemia 、 Central nervous system disease 、 Nuclear medicine 、 Vascular disease 、 Abnormality 、 Magnetic resonance imaging 、 Medicine
摘要: Cerebral tissue with T2 magnetic resonance imaging (MRI) abnormalities following stroke is generally considered infarcted, while surrounding regions normal MRI appearance are believed to be healthy. To assess whether these consist of tissue, we explored the distribution N-acetylaspartate (NAA) and lactate within around hyperintense area on T2-weighted using proton MR spectroscopy. The study was carried out in 25 patients middle cerebral artery occlusion imaged between 1 42 days after onset. NAA/choline (Cho) ratios were significantly reduced both areas hyperintensity tissue. reduction greater region than (-50% vs. -28%, respectively) unrelated delay ictus. Lactate/Cho increased massively abnormal area, but did not differ from control values beyond margin hyperintensity. Overall data indicate that visible lesions do infer entire injured
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Céline Demougeot, Philippe Garnier, Claude Mossiat, Nathalie Bertrand, Maurice Giroud, Alain Beley, Christine Marie, N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury Journal of Neurochemistry. ,vol. 77, pp. 408- 415 ,(2001) , 10.1046/J.1471-4159.2001.00285.X
A. Connelly, W. Van Paesschen, D. A. Porter, C. L. Johnson, J. S. Duncan, D. G. Gadian, Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy Neurology. ,vol. 51, pp. 61- 66 ,(1998) , 10.1212/WNL.51.1.61
Norman J. Beauchamp, Peter B. Barker, Paul Y. Wang, Peter C. M. vanZijl, Imaging of acute cerebral ischemia. Radiology. ,vol. 212, pp. 307- 324 ,(1999) , 10.1148/RADIOLOGY.212.2.R99AU16307
Thomas Nikolaj Sager, Christian Thomsen, Jacob Stenmann Valsborg, Henning Laursen, Anker Jon Hansen, Astroglia contain a specific transport mechanism for N-acetyl-L-aspartate. Journal of Neurochemistry. ,vol. 73, pp. 807- 811 ,(2002) , 10.1046/J.1471-4159.1999.0730807.X
JOHN P. MacMANUS, ALASTAIR M. BUCHAN, Apoptosis after experimental stroke: fact or fashion? Journal of Neurotrauma. ,vol. 17, pp. 899- 914 ,(2000) , 10.1089/NEU.2000.17.899
P Gideon, B Sperling, P Arlien-Søborg, T S Olsen, O Henriksen, Long-term follow-up of cerebral infarction patients with proton magnetic resonance spectroscopy. Stroke. ,vol. 25, pp. 967- 973 ,(1994) , 10.1161/01.STR.25.5.967
J W Berkelbach van der Sprenkel, P R Luyten, P C van Rijen, C A Tulleken, J A den Hollander, Cerebral lactate detected by regional proton magnetic resonance spectroscopy in a patient with cerebral infarction. Stroke. ,vol. 19, pp. 1556- 1560 ,(1988) , 10.1161/01.STR.19.12.1556
P B Barker, J H Gillard, P C van Zijl, B J Soher, D F Hanley, A M Agildere, S M Oppenheimer, R N Bryan, Acute stroke: evaluation with serial proton MR spectroscopic imaging. Radiology. ,vol. 192, pp. 723- 732 ,(1994) , 10.1148/RADIOLOGY.192.3.8058940
M. Lemesle, C. Milan, J. Faivre, T. Moreau, M. Giroud, R. Dumas, Incidence Trends of Ischemic Stroke and Transient Ischemic Attacks in a Well-Defined French Population From 1985 Through 1994 Stroke. ,vol. 30, pp. 371- 377 ,(1999) , 10.1161/01.STR.30.2.371
Thomas Nikolaj Sager, Henning Laursen, Anker Jon Hansen, Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat. Journal of Cerebral Blood Flow and Metabolism. ,vol. 15, pp. 639- 646 ,(1995) , 10.1038/JCBFM.1995.79