New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches
作者： Joshua J. Obar , Tobias M. Hohl , Robert A. Cramer
DOI: 10.1016/J.CYTO.2016.05.015
关键词: Immunology 、 Aspergillosis 、 Important research 、 Neuroscience 、 Effector 、 Biology 、 Immune effector cell 、 Precision medicine 、 Antifungal 、 Disease 、 Immune compromised
摘要: Invasive aspergillosis (IA) remains a devastating disease in immune compromised patients despite significant advances our understanding of fungal virulence and host defense mechanisms. In this review, we summarize important research the fight against IA with particular focus on early events interactions between Aspergillus fumigatus that occur respiratory tract. Advances mechanisms effector cell recruitment, antifungal mechanisms, how dynamic host-fungal interaction alters local microenvironment to effect outcomes are highlighted. These illustrate exciting new therapeutic opportunities, but also emphasize importance each unique fungus-host for improving patient outcomes.
sci-hub.se 参考文章(121)
Sandra Bruns, Olaf Kniemeyer, Mike Hasenberg, Vishukumar Aimanianda, Sandor Nietzsche, Andreas Thywißen, Andreas Jeron, Jean-Paul Latgé, Axel A. Brakhage, Matthias Gunzer, Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA PLOS Pathogens. ,vol. 6, ,(2010) , 10.1371/JOURNAL.PPAT.1000873
Ronen Ben-Ami, Russell E. Lewis, Konstantinos Leventakos, Dimitrios P. Kontoyiannis, Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites Blood. ,vol. 114, pp. 5393- 5399 ,(2009) , 10.1182/BLOOD-2009-07-231209
Yue Zheng, Melanie Humphry, Janet J. Maguire, Martin R. Bennett, Murray C.H. Clarke, Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation Immunity. ,vol. 38, pp. 285- 295 ,(2013) , 10.1016/J.IMMUNI.2013.01.008
M. Ivan, K. Kondo, H. Yang, W. Kim, J. Valiando, M. Ohh, A. Salic, J. M. Asara, W. S. Lane, W. G. Kaelin, HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing Science. ,vol. 292, pp. 464- 468 ,(2001) , 10.1126/SCIENCE.1059817
Vanessa Espinosa, Anupam Jhingran, Orchi Dutta, Shinji Kasahara, Robert Donnelly, Peicheng Du, Jeffrey Rosenfeld, Ingrid Leiner, Chiann-Chyi Chen, Yacov Ron, Tobias M. Hohl, Amariliz Rivera, Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung PLoS Pathogens. ,vol. 10, pp. e1003940- ,(2014) , 10.1371/JOURNAL.PPAT.1003940
S. SCHELENZ, D. A. SMITH, G. J. BANCROFT, Cytokine and chemokine responses following pulmonary challenge with Aspergillus fumigatus: obligatory role of TNF-α and GM-CSF in neutrophil recruitment Medical Mycology. ,vol. 37, pp. 183- 194 ,(1999) , 10.1046/J.1365-280X.1999.00219.X
Sixto M. Leal, Susan Cowden, Yen-Cheng Hsia, Mahmoud A. Ghannoum, Michelle Momany, Eric Pearlman, Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis PLOS Pathogens. ,vol. 6, pp. 1- 16 ,(2010) , 10.1371/JOURNAL.PPAT.1000976
Tobias M Hohl, Heather L. Van Epps, Amariliz Rivera, Laura A Morgan, Patrick L Chen, Marta Feldmesser, Eric G Pamer, Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display PLOS Pathogens. ,vol. 1, pp. 232- 240 ,(2005) , 10.1371/JOURNAL.PPAT.0010030
Cecilia Garlanda, Emilio Hirsch, Silvia Bozza, Antonietta Salustri, Marika De Acetis, Rachele Nota, Alessia Maccagno, Federica Riva, Barbara Bottazzi, Giuseppe Peri, Andrea Doni, Luca Vago, Marina Botto, Rita De Santis, Paolo Carminati, Gregorio Siracusa, Fiorella Altruda, Annunciata Vecchi, Luigina Romani, Alberto Mantovani, Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response Nature. ,vol. 420, pp. 182- 186 ,(2002) , 10.1038/NATURE01195
Matteo Bianchi, Maria J. Niemiec, Ulrich Siler, Constantin F. Urban, Janine Reichenbach, Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent The Journal of Allergy and Clinical Immunology. ,vol. 127, pp. 1243- 1252 ,(2011) , 10.1016/J.JACI.2011.01.021