Effect of vonoprazan on the treatment of artificial gastric ulcers after endoscopic submucosal dissection: Prospective randomized controlled trial.

摘要: Background and Aim Proton pump inhibitors are effective for the treatment of gastric ulcers after endoscopic submucosal dissection (ESD). However, most excellent therapy is controversial. Vonoprazan, an active potassium-competitive acid blocker, has a strong secretion inhibitory effect, but its efficacy post-ESD unclear. Herein, we aimed to determine healing effect vonoprazan on ulcers. Methods We carried out prospective randomized controlled trial examining 92 patients who had undergone ESD neoplasms between April 2015 June 2016 at Machida Municipal Hospital. Patients were treated with 20 mg/day (V group) or esomeprazole (E 8 weeks. We evaluated 8-week cure rate artificial any complications ESD. Results A total 80 (median age, 73.5 years; 71.3% male) analyzed. Cure V group was significantly higher than that E (94.9% [37/39] vs 78.0% [32/41], respectively; P = 0.049). In multivariate analysis, only correlated ulcer (odds ratio 6.33; 95% CI 1.21–33.20; 0.029). Delayed bleeding experienced in (7.3% [3/41]), no significant difference compared observed (P 0.241). Conclusion Vonoprazan superior should be considered as first choice.