Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate

摘要: Exposure to stressful events early in life may have permanent deleterious consequences on nervous system function and increase the susceptibility psychiatric conditions later life. Maternal deprivation, commonly used as a source of neonatal stress, impairs memory adult rats reduces hippocampal brain-derived neurotrophic factor (BDNF) levels. Inflammatory cytokines, such interleukins (IL) tumor necrosis factor-α (TNF-α) been shown be increased peripheral blood patients with disorders. The aim present study was investigate effects maternal separation levels IL-10 TNF-α, BDNF hippocampus prefrontal cortex rats. We also evaluated potential ameliorating properties topiramate valproic acid deficits cytokine changes associated deprivation. results indicated that, addition inducing deficits, deprivation hippocampus, TNF-α cortex, decreased BDNF, Neither nor were able ameliorate or reduction induced by separation. highest dose reduce while valproate only reduced hippocampus. These findings implications for better understanding mechanisms alterations observed events, proposal novel therapeutic strategies.