Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer.
作者： A Webb , D Cunningham , J H Scarffe , P Harper , A Norman
DOI: 10.1200/JCO.1997.15.1.261
关键词: Surgery 、 Fluorouracil 、 Epirubicin 、 Stomach cancer 、 Internal medicine 、 Methotrexate 、 Gastroenterology 、 Chemotherapy 、 Medicine 、 ECF Regimen 、 Randomization 、 Toxicity
摘要: PURPOSEWe report the results of a prospectively randomized study that compared combination epirubicin, cisplatin, and protracted venous infusion fluorouracil (5-FU) (ECF regimen) with standard 5-FU, doxorubicin, methotrexate (FAMTX) in previously untreated patients advanced esophagogastric cancer.PATIENTS AND METHODSTwo hundred seventy-four adenocarcinoma or undifferentiated carcinoma were analyzed for survival, tumor response, toxicity, quality life (QL).RESULTSThe overall response rate was 45% (95% confidence interval [CI], 36% to 54%) ECF 21% CI, 13% 29%) FAMTX (P = .0002). Toxicity tolerable there only three toxic deaths. The regimen caused more hematologic toxicity serious infections, but emesis alopecia. median survival duration 8.9 months 5.7 .0009); at 1 year, 27% 45%) 14% ...
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