Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.
作者： Sun Nam Kim , Jae Yeol Lee , Hyoung Ja Kim , Cha-Gyun Shin , Hokoon Park
DOI: 10.1016/S0960-894X(00)00355-3
关键词: Enzyme inhibitor 、 Chemical synthesis 、 Glycoside 、 Integrase 、 IC50 、 Enzyme 、 Chemistry 、 In vitro 、 Linker 、 Stereochemistry 、 Biochemistry
摘要: Abstract Caffeoylglucosides, which have a glucose ring as central linker, were synthesized from methyl d -glucosides, and their anti-HIV-1 activities tested. Among them, four dicaffeoylglucosides (IC50=29.1–35.1 μM), 6a , 6b 9b 10b showed HIV-1 integrase inhibitory activity potent l -chicoric acid.
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