Magnetic nano-Fe3O4 particles targeted gathering and bio-effects on nude mice loading human hepatoma Bel-7402 cell lines model under external magnetic field exposure in vivo.
作者： Zhiqiang Chen , Jian Wen , Huixiang Ju , Zheng Fang
DOI: 10.3109/15368378.2014.919589
关键词: Magnetic resonance imaging 、 Magnetic field exposure 、 In vivo 、 Nuclear magnetic resonance 、 BAX Protein 、 Chemistry 、 Cancer research 、 Physiological function 、 Cell culture 、 Apoptosis 、 Tail vein
摘要: AbstractMagnetic nano-Fe3O4 particles (MNPs), static magnetic field (SMF) and extremely low-frequency altering electric (ELFF) were utilized to treat nude mice loading hepatoma Bel-7402 cell lines investigate the therapeutic values of MNPs combined with ELFF in vivo. Magnetic resonance image (MRI) figures showed that about 98.9% injected into body through tail vein gathered tumor focal by SMF directing exposure. Single treatments did not influence physiological function obviously. However, treatment prolonged survival time inhibited cells proliferation significantly compared other groups (p < 0.05); furthermore, early apoptosis ratio group was higher than (p < 0.05), improved associated Bcl protein expression: Bax expression Bcl-2...
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