Polymerase Chain Reaction Analysis of Immunoglobulin Gene Rearrangement in Cutaneous Lymphoid Hyperplasias

摘要: Background The differential diagnosis of cutaneous lymphoid hyperplasia and B-cell lymphoma may be difficult. Whether the detection clonal immunoglobulin gene rearrangement in lesion is predictive a malignant outcome remains controversial. We therefore studied cases by polymerase chain reaction analysis. Design Retrospective study patients seen between 1988 1996. Setting Two dermatology university departments. Patients Twenty-four with hyperplasias were included according to clinical, histopathological, immunophenotypic criteria. Main Outcome Measures Clinical, laboratory findings. Results There 13 men 11 women (mean age, 49 years) who presented erythematous or violaceous papules nodules. lesions unique multiple cases. All had immunochemical evidence mixed T- infiltrate polytypic B cells. Polyclonality was demonstrated 23 patients, whereas dominant clone detected 1 patient. No developed during follow-up (median, 4 years). In same period, we 53 lymphomas. Thirty-five (66%) detectable rearrangement. Conclusions majority our cases, polyclonality analysis accordance hyperplasia. 24 presence could evidenced. This fact did not modify treatment as there no histological signs suggestive lymphoma.