Strain and model differences in behavioral outcomes after spinal cord injury in rat.
作者： Charles D. Mills , Bryan C. Hains , Kathia M. Johnson , Claire E. Hulsebosch
DOI: 10.1089/089771501316919111
关键词: Spinal cord 、 Chronic pain 、 Sprague dawley rats 、 Stimulation 、 Central nervous system disease 、 Strain (injury) 、 Thermal stimulation 、 Medicine 、 Spinal cord injury 、 Anesthesia
摘要: Spinal cord injury (SCI) results in loss of function below the level and development chronic central pain (CCP) syndromes. Since different strains may develop express behaviors differently, we evaluated behavioral outcomes (locomotor recovery mechanical thermal allodynia) three commonly used rats (Long-Evans, Wistar, Sprague-Dawley) using two models SCI. The examined were contusion at T10 (NYU impactor, 12.5 mm height) T13 hemisection. Mechanical stimulation (von Frey filaments) revealed significantly lower baseline responses for Long-Evans higher paw withdrawal latencies to Wistar compared other strains. Following SCI, had highest percentage animals that developed allodynia (73%), while Sprague-Dawley percentages (75%) following hemisection Interestingly, (87%) 100% both Sprague Dawley model. Locomotor after SCI was similar each model recovered slower a lesser extent than In model, faster achieved greater function. Overall, produced larger CCP stimulation. Thus, it appears strain selection has impact on locomotor Furthermore, these suggest genetic factors play role
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