Essential fatty acid diet supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats.

摘要: Effects of essential fatty acids on nerve conduction, hypoxic resistance, skeletal muscle contractile properties, and capillary density were examined in streptozocin-induced diabetic rats. Nondiabetic controls three groups treated with 10% supplements corn oil, evening primrose oil (Efamol), or a mixture 80% 20% fish (Efamol Marine) for 2 mo used. Efamol Marine increased plasma gamma-linolenic acid levels, but arachidonic was elevated only Efamol. Diabetes resulted 15-29% reductions sciatic motor sensory saphenous conduction velocity. prevented deficits more effectively than Marine, had no effect. In vitro measurement resistance revealed 49% increase the time taken action potential amplitude to decline by 50% diabetes. Corn significant With Efamol, within nondiabetic range. produced intermediate results. Functional improvements may relate enhanced vasa nervorum perfusion, because endoneurial 22% angiogenesis perhaps resulting from eicosanoid production acid. Soleus contractions prolonged This partially corrected treatment, being most effective. Extensor digitorum longus reduced tetanic tension diabetes, this all treatments. showed modest capillarization which have contributed susceptibility fatigue. The data suggest involvement abnormal metabolism etiology neuropathy myopathy.