作者: Katherine L. Nathanson
DOI: 10.1007/978-1-4419-0477-5_7
关键词: Oncology 、 Increased risk 、 Cancer 、 Hereditary Breast Cancer 、 Internal medicine 、 Gene 、 Fanconi anemia 、 Cancer susceptibility 、 Cowden syndrome 、 Medicine 、 Breast cancer
摘要: The major genes associated with inherited susceptibility to breast cancer are BRCA1 and BRCA2. However, is a component of other syndromes, including Li-Fraumeni syndrome, Cowden Peutz-Jeghers syndrome Hereditary Gastric Cancer. This chapter divided into two parts: (1) rare familial syndromes as (Table 7.1) (2) mutations in DNA damage response an increased risk cancer, notably families multiple cases.