TfR2 links iron metabolism and erythropoiesis.
DOI: 10.1182/BLOOD-2014-12-617571
关键词: Negative regulator 、 Metabolism 、 Biology 、 Internal medicine 、 Erythropoiesis 、 Endocrinology 、 Transferrin receptor 、 Function (biology)
摘要: In this issue of Blood , Nai et al establish a function transferrin receptor 2 (TfR2) as negative regulator erythropoiesis.[1][1] ![Figure][2] A model for the hepatic and erythroid TfR2 in control systemic iron metabolism erythropoiesis. (A) an iron-replete
ashpublications.org
bloodjournal.org参考文章(10)
Nicole Wilkinson, Kostas Pantopoulos, IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation Blood. ,vol. 122, pp. 1658- 1668 ,(2013) , 10.1182/BLOOD-2013-03-492454
Christal A. Worthen, Caroline A. Enns, The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body. Frontiers in Pharmacology. ,vol. 5, pp. 34- 34 ,(2014) , 10.3389/FPHAR.2014.00034
Léon Kautz, Grace Jung, Erika V Valore, Stefano Rivella, Elizabeta Nemeth, Tomas Ganz, None, Identification of erythroferrone as an erythroid regulator of iron metabolism Nature Genetics. ,vol. 46, pp. 678- 684 ,(2014) , 10.1038/NG.2996
Paul L Auer, Alexander Teumer, Ursula Schick, Andrew O'Shaughnessy, Ken Sin Lo, Nathalie Chami, Chris Carlson, Simon de Denus, Marie-Pierre Dubé, Jeff Haessler, Rebecca D Jackson, Charles Kooperberg, Louis-Philippe Lemieux Perreault, Matthias Nauck, Ulrike Peters, John D Rioux, Frank Schmidt, Valérie Turcot, Uwe Völker, Henry Völzke, Andreas Greinacher, Li Hsu, Jean-Claude Tardif, George A Diaz, Alexander P Reiner, Guillaume Lettre, Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits Nature Genetics. ,vol. 46, pp. 629- 634 ,(2014) , 10.1038/NG.2962
Antonella Nai, Maria Rosa Lidonnici, Marco Rausa, Giacomo Mandelli, Alessia Pagani, Laura Silvestri, Giuliana Ferrari, Clara Camaschella, The second transferrin receptor regulates red blood cell production in mice Blood. ,vol. 125, pp. 1170- 1179 ,(2015) , 10.1182/BLOOD-2014-08-596254
Hana Forejtnikovà, Maud Vieillevoye, Yael Zermati, Mireille Lambert, Rosa Maria Pellegrino, Soizic Guihard, Muriel Gaudry, Clara Camaschella, Catherine Lacombe, Antonella Roetto, Patrick Mayeux, Frédérique Verdier, Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood. ,vol. 116, pp. 5357- 5367 ,(2010) , 10.1182/BLOOD-2010-04-281360
Konstantinos Gkouvatsos, George Papanikolaou, Kostas Pantopoulos, Regulation of iron transport and the role of transferrin. Biochimica et Biophysica Acta. ,vol. 1820, pp. 188- 202 ,(2012) , 10.1016/J.BBAGEN.2011.10.013
Nicole Soranzo, Tim D Spector, Massimo Mangino, Brigitte Kühnel, Augusto Rendon, Alexander Teumer, Christina Willenborg, Benjamin Wright, Li Chen, Mingyao Li, Perttu Salo, Benjamin F Voight, Philippa Burns, Roman A Laskowski, Yali Xue, Stephan Menzel, David Altshuler, John R Bradley, Suzannah Bumpstead, Mary-Susan Burnett, Joseph Devaney, Angela Döring, Roberto Elosua, Stephen E Epstein, Wendy Erber, Mario Falchi, Stephen F Garner, Mohammed J R Ghori, Alison H Goodall, Rhian Gwilliam, Hakon H Hakonarson, Alistair S Hall, Naomi Hammond, Christian Hengstenberg, Thomas Illig, Inke R König, Christopher W Knouff, Ruth McPherson, Olle Melander, Vincent Mooser, Matthias Nauck, Markku S Nieminen, Christopher J O'Donnell, Leena Peltonen, Simon C Potter, Holger Prokisch, Daniel J Rader, Catherine M Rice, Robert Roberts, Veikko Salomaa, Jennifer Sambrook, Stefan Schreiber, Heribert Schunkert, Stephen M Schwartz, Jovana Serbanovic-Canic, Juha Sinisalo, David S Siscovick, Klaus Stark, Ida Surakka, Jonathan Stephens, John R Thompson, Uwe Völker, Henry Völzke, Nicholas A Watkins, George A Wells, H-Erich Wichmann, David A Van Heel, Chris Tyler-Smith, Swee Lay Thein, Sekar Kathiresan, Markus Perola, Muredach P Reilly, Alexandre F R Stewart, Jeanette Erdmann, Nilesh J Samani, Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H Ouwehand, Christian Gieger, A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium Nature Genetics. ,vol. 41, pp. 1182- 1190 ,(2009) , 10.1038/NG.467
A. Nai, R. M. Pellegrino, M. Rausa, A. Pagani, M. Boero, L. Silvestri, G. Saglio, A. Roetto, C. Camaschella, The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice. Haematologica. ,vol. 99, pp. 1016- 1021 ,(2014) , 10.3324/HAEMATOL.2013.103143
Tomas Ganz, Systemic Iron Homeostasis Physiological Reviews. ,vol. 93, pp. 1721- 1741 ,(2013) , 10.1152/PHYSREV.00008.2013