Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles.
作者： Saowanee Jaraswekin , Sompol Prakongpan , Roland Bodmeier
DOI: 10.1080/02652040701233655
关键词: Materials science 、 Aqueous two-phase system 、 Sodium 、 Liberation 、 Microparticle 、 Polymer 、 Nuclear chemistry 、 Dexamethasone Sodium Phosphate 、 PLGA 、 Organic chemistry 、 Molecular mass
摘要: The objective of this study was to investigate the effect poly(lactide-co-glycolide) (PLGA) molecular weight (Resomer® RG 502H, 503H, and 504H) on release behavior dexamethasone sodium phosphate-loaded microparticles. microparticles were prepared by three modifications solvent evaporation method (O/W-cosolvent, O/W-dispersion, W/O/W-methods). encapsulation efficiency cosolvent- W/O/W-methods increased from ∼50% >90% upon addition NaCl external aqueous phase, while dispersion resulted in lower efficiencies. phosphate PLGA (>50 µm) biphasic. initial burst correlated well with porosity microparticles, both which increasing polymer (RG 504H > 503H > 502H). also dependent preparation order method > WOW method > consolvent meth...
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