Immunophenotypic profile and increased risk of hospital admission for infection in infants born to female kidney transplant recipients.
作者： E. Ono , A. M. dos Santos , P. O. Viana , M. I. S. Dinelli , N. Sass
DOI: 10.1111/AJT.13143
关键词: CD8 、 Pregnancy 、 Physiology 、 Gestation 、 Hospital admission 、 Immunology 、 Immunosuppression 、 Clinical research 、 Kidney 、 Immune system 、 Medicine
摘要: Children born to female kidney recipients are exposed immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children and 40 full-term healthy mothers were evaluated. T, B, NK, NKT, γδT cells assessed by flow cytometry functional evaluation of T dendritic after vitro activation was performed 8 months age. At birth, infants showed lower numbers CD4+ NKT intense reduction B (median cells/mm(3) , transplant: 153.7 X control: 512.4; p < 0.001). There also a reduced percentage activated CD8+ regulatory cells. Activated memory exhausted higher percentages among immunosuppressors when compared control group. months, most alterations no longer observed, but four still had low some lymphocyte subsets this 4.351 (95% CI: 1.026-15.225; p = 0.046) risk hospital admission first life-some, with severe clinical manifestations-than those women.
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