Serotonergic psychedelics and personality: A systematic review of contemporary research.
作者： José Carlos Bouso , Rafael G. dos Santos , Miguel Ángel Alcázar-Córcoles , Jaime E.C. Hallak
DOI: 10.1016/J.NEUBIOREV.2018.02.004
关键词: Psychology 、 Openness to experience 、 Personality 、 Big Five personality traits 、 Hallucinogen 、 Personality changes 、 Psychedelic drug 、 Clinical psychology 、 Serotonergic 、 Posterior cingulate
摘要: Serotonergic psychedelics act as agonists at cortical 5-HT2A receptors and seem to induce personality changes. We conducted a systematic review of studies assessing the effects these drugs on personality. Papers published from 1985-2016 were included PubMed, LILACS, SciELO databases. Three hundred sixty-nine identified, 18 included. Specific traits, such Absorption Self-Transcendence, influence psychedelics, psychedelic drug users nonusers appear differ in some traits. Psychedelics administered controlled settings may changes, increased Openness Self-Transcendence. Increases global brain entropy induced by acute administration predicted changes Openness, Self-Transcendence was negatively correlated with thinning posterior cingulate cortex long-term religious ayahuasca users. Acute use is associated that be modulated receptors. These therapeutic should further explored randomized studies.
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