Consensus Paper. Cerebellar Reserve: From Cerebellar Physiology to Cerebellar Disorders.

摘要: Cerebellar reserve refers to the capacity of cerebellum compensate for tissue damage or loss function resulting from many different etiologies. When inciting event produces acute focal (e.g., stroke, trauma), impaired cerebellar may be compensated by other areas extracerebellar structures (i.e., structural reserve). In contrast, when pathological changes compromise neuronal integrity gradually leading cell death metabolic and immune-mediated ataxias, neurodegenerative ataxias), it is possible that affected area itself can slowly evolving lesion functional Here, we examine perspective three cornerstones clinical ataxiology: control ocular movements, coordination voluntary axial appendicular cognitive functions. Current evidence indicates potentiated environmental enrichment through mechanisms autophagy synaptogenesis, suggesting not rigid fixed, but exhibits plasticity experience. These conclusions have therapeutic implications. During period preserved, treatments should directed at stopping disease progression and/or limiting process. Simultaneously, using multiple approaches. Potentiation lead compensation restoration in setting diseases, also disorders primarily cerebral hemispheres enhancing action. It therefore appears reserve, underlying microcircuitry enables it, critical neurobiological importance a wide range neurological/neuropsychiatric conditions.