Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer
作者： Nadine Tung , Nancy U. Lin , John Kidd , Brian A. Allen , Nanda Singh
关键词: Gene 、 Triple Negative Breast Neoplasms 、 Germline mutation 、 Germline 、 Genetic testing 、 Cancer 、 Prospective cohort study 、 Medicine 、 Breast cancer 、 Bioinformatics
摘要: PurposeTesting for germline mutations in BRCA1/2 is standard select patients with breast cancer to guide clinical management. Next-generation sequencing (NGS) allows testing additional predisposition genes. The frequency of detected by using NGS has been reported who were referred or triple-negative cancer. We assessed the and predictors 25 genes, including BRCA1/2, a sequential series at an academic institution examine utility genetic this population.MethodsPatients stages I III seen single center between 2010 2012, agreed participate research DNA banking, included (N = 488). Personal family histories collected was sequenced identify mutations.ResultsDeleterious id...
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