COX‐2, TFF1, and Src define better prognosis in young patients with gastric cancer

摘要: Background and Objectives Despite its dwindling occurrence, gastric cancer remains a leading cause of related mortality worldwide. Molecular determinants prognosis that impact survival are being sought out as means to facilitate rational clinical decision-making enhance patient management. In this study, we evaluated three molecules implicated in carcinogenesis demonstrated the differential expression cyclooxygenase-2 (COX-2) viral oncogene homolog Src proteins could explain differences observed patients older younger than 50 years age. Methods We 5-year cohort 423 using chronological age variable. Additionally, assessed protein (COX-2, TFF1, Src) pathogenesis immunohistochemistry. Results We found had better rate all tumor stages. We COX-2 correlated significantly with group without any significant attributable TFF1. Conclusions Our study demonstrates young have prognostic outlook part be explained by Src. J. Surg. Oncol. 2013; 108:409–413. © 2013 Wiley Periodicals, Inc.