Serum corticosteroid binding globulin expression is modulated by fasting in polar bears (Ursus maritimus)
作者： Brian A. Chow , Jason Hamilton , Marc R.L. Cattet , Gordon Stenhouse , Martyn E. Obbard
DOI: 10.1016/J.CBPA.2010.09.017
关键词: Creatinine 、 Transcortin 、 Fight-or-flight response 、 Cortisol binding 、 Ursus maritimus 、 Serum urea 、 Protein expression 、 Internal medicine 、 Biology 、 Metabolic state 、 Endocrinology
摘要: Abstract Polar bears ( Ursus maritimus ) from several subpopulations undergo extended fasting during the ice-free season. However, animals appear to conserve protein despite prolonged fasting, though mechanisms involved are poorly understood. We hypothesized that elevated concentrations of corticosteroid binding globulin (CBG), primary cortisol in circulation, lead resistance and provide a mechanism for conservation fasting. The metabolic state (feeding vs. fasting) 16 field sampled male polar was determined based on their serum urea creatinine ratio (> 25 feeding
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